Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
USERS' SCORE
Moderately Good
Based on 107 Reviews
7.8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Rutin Powder (non-citrus source)(Sophora japonica) (Flower Bud)
450 mg
*
Top Medical Research Studies
9
We found that quercetin-3-rutinoside, a flavonoid, effectively inhibits blood clot formation in mice. This compound works by targeting an enzyme called protein disulfide isomerase (PDI), which is crucial for the clumping of platelets and the creation of fibrin, a key component of clots.
Our experiments revealed that quercetin-3-rutinoside binds to a specific region of PDI, altering its structure and reducing its activity. Interestingly, introducing a fragment of PDI could reverse the clot-inhibiting effects of quercetin-3-rutinoside. Overall, this study suggests that quercetin-3-rutinoside may have potential as a natural antithrombotic agent.
Our experiments revealed that quercetin-3-rutinoside binds to a specific region of PDI, altering its structure and reducing its activity. Interestingly, introducing a fragment of PDI could reverse the clot-inhibiting effects of quercetin-3-rutinoside. Overall, this study suggests that quercetin-3-rutinoside may have potential as a natural antithrombotic agent.
Read More
8
We examined the effects of rutin, a natural compound found in Dendropanax morbifera, on blood clotting. Through a detailed chemical analysis, we discovered that rutin has a significant impact on reducing fibrin clots and prolonging clotting times in the lab.
In mouse studies, rutin showed a strong protective effect against blood clots caused by certain triggers. Overall, these findings point to rutin's potential as a natural remedy for preventing blood clots and improving cardiovascular health.
In mouse studies, rutin showed a strong protective effect against blood clots caused by certain triggers. Overall, these findings point to rutin's potential as a natural remedy for preventing blood clots and improving cardiovascular health.
Read More
9
We investigated how rutin can be effectively delivered to combat blood clots. Our study focused on creating special liposomes that can specifically target blood platelets. Through various blood tests, we found that the targeted liposomes—combined with abciximab or RGD peptide—showed significantly better antithrombotic effects than rutin alone.
Importantly, these formulations also increased the drug's bioavailability and demonstrated safety in tests with animals. Overall, targeted rutin-loaded liposomes could offer a promising approach for improving treatment against blood clots.
Importantly, these formulations also increased the drug's bioavailability and demonstrated safety in tests with animals. Overall, targeted rutin-loaded liposomes could offer a promising approach for improving treatment against blood clots.
Read More
Most Useful Reviews
9
Impressive results
43 people found this helpful
Vessels appreciate him. I procured this for my mother and have observed significant improvement in her blood vessels' condition after using the drug alongside resveratrol and coenzyme Q10. Rutin reduces blood vessel permeability and bolsters their walls while enhancing ascorbic acid absorption. The diagnostics conducted before and after the treatment were remarkably impressive. Highly recommend this for anyone seeking to improve vascular health. Wishing everyone good health!
Read More
9
Improves blood circulation
10 people found this helpful
Rutin is prescribed for ulcers, hypertension, and atherosclerosis, crucial for blood vessel health. It enhances red blood cell elasticity, improves blood flow, and dilates vessels to prevent blood clots and varicose veins. I recommend this company as their product has no side effects.
Read More
9
Complications help
9 people found this helpful
Excellent! Did you know that COVID-19 (or rather, its toxin) affects the inner wall of blood vessels, making them thinner and rougher? This can lead to complications, such as blood clot formation. Rutin is an amino acid that helps address these issues. Be sure to follow the dosage instructions for at least two months during viral illnesses. Additionally, enjoy blackcurrants in summer for their high rutin content and stay healthy!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
- All Researches
9
We investigated how rutin can be effectively delivered to combat blood clots. Our study focused on creating special liposomes that can specifically target blood platelets. Through various blood tests, we found that the targeted liposomes—combined with abciximab or RGD peptide—showed significantly better antithrombotic effects than rutin alone.
Importantly, these formulations also increased the drug's bioavailability and demonstrated safety in tests with animals. Overall, targeted rutin-loaded liposomes could offer a promising approach for improving treatment against blood clots.
Importantly, these formulations also increased the drug's bioavailability and demonstrated safety in tests with animals. Overall, targeted rutin-loaded liposomes could offer a promising approach for improving treatment against blood clots.
Read More
9
We examined how rutin, a potent inhibitor of protein disulfide isomerase, impacts blood clot formation. By creating a lipid-based nano-formulation of rutin, we enhanced its solubility and bioavailability.
In our tests, this formulation significantly reduced thrombin generation and clot formation in mice, outperforming traditional options in various models of thrombosis. Remarkably, further analysis affirmed its specificity and safety, indicating that our nano-formulation could be a viable antithrombotic treatment suitable for clinical use.
In our tests, this formulation significantly reduced thrombin generation and clot formation in mice, outperforming traditional options in various models of thrombosis. Remarkably, further analysis affirmed its specificity and safety, indicating that our nano-formulation could be a viable antithrombotic treatment suitable for clinical use.
Read More
9
We found that quercetin-3-rutinoside, a flavonoid, effectively inhibits blood clot formation in mice. This compound works by targeting an enzyme called protein disulfide isomerase (PDI), which is crucial for the clumping of platelets and the creation of fibrin, a key component of clots.
Our experiments revealed that quercetin-3-rutinoside binds to a specific region of PDI, altering its structure and reducing its activity. Interestingly, introducing a fragment of PDI could reverse the clot-inhibiting effects of quercetin-3-rutinoside. Overall, this study suggests that quercetin-3-rutinoside may have potential as a natural antithrombotic agent.
Our experiments revealed that quercetin-3-rutinoside binds to a specific region of PDI, altering its structure and reducing its activity. Interestingly, introducing a fragment of PDI could reverse the clot-inhibiting effects of quercetin-3-rutinoside. Overall, this study suggests that quercetin-3-rutinoside may have potential as a natural antithrombotic agent.
Read More
9
Morus alba shows anti-clotting effects
We investigated the potential of Morus alba leaves (MAE) to reduce blood clotting, particularly looking at its effects on platelet aggregation. Using rat platelets, we found that MAE significantly inhibited collagen-induced platelet aggregation in a dose-dependent manner. Additionally, it reduced the secretion of serotonin and thromboxane A2, key players in clot formation. In vivo, MAE also demonstrated the ability to decrease thrombus formation effectively in a rat model. This suggests that Morus alba leaves could be a promising natural option for anti-platelet treatment.
Read More
9
We explored the potential of quercetin-3-rutinoside, a compound that inhibits protein disulfide isomerase (PDI), in preventing blood clots. Through a series of tests, we found that this compound effectively stopped platelet aggregation and fibrin formation, which are crucial steps in clot development.
Using advanced imaging techniques in mice, we confirmed that quercetin-3-rutinoside successfully blocked thrombus formation. Interestingly, introducing PDI back into the system reversed its antithrombotic effects, pointing to PDI's role as a promising target for new clot-preventing treatments.
Using advanced imaging techniques in mice, we confirmed that quercetin-3-rutinoside successfully blocked thrombus formation. Interestingly, introducing PDI back into the system reversed its antithrombotic effects, pointing to PDI's role as a promising target for new clot-preventing treatments.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 107 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Impressive results
43 people found this helpful
Vessels appreciate him. I procured this for my mother and have observed significant improvement in her blood vessels' condition after using the drug alongside resveratrol and coenzyme Q10. Rutin reduces blood vessel permeability and bolsters their walls while enhancing ascorbic acid absorption. The diagnostics conducted before and after the treatment were remarkably impressive. Highly recommend this for anyone seeking to improve vascular health. Wishing everyone good health!
Read More
9
Improves blood circulation
10 people found this helpful
Rutin is prescribed for ulcers, hypertension, and atherosclerosis, crucial for blood vessel health. It enhances red blood cell elasticity, improves blood flow, and dilates vessels to prevent blood clots and varicose veins. I recommend this company as their product has no side effects.
Read More
9
Complications help
9 people found this helpful
Excellent! Did you know that COVID-19 (or rather, its toxin) affects the inner wall of blood vessels, making them thinner and rougher? This can lead to complications, such as blood clot formation. Rutin is an amino acid that helps address these issues. Be sure to follow the dosage instructions for at least two months during viral illnesses. Additionally, enjoy blackcurrants in summer for their high rutin content and stay healthy!
Read More
9
Supports vascular health
7 people found this helpful
Rutin is excellent for those with blood vessel issues from fragility to migraines. I recommend combining it with vitamin C and an anti-varicose complex. It’s irreplaceable for people facing similar problems; compared to other products, it’s far more effective!
Read More
9
Improves warmth
6 people found this helpful
After years of suffering from cold hands and feet, I began taking rutin. Eventually, my extremities became too warm, prompting me to reduce my intake to a capsule once a month for maintenance. My hands and feet now feel comfortably warm. However, I would avoid this product if using blood thinners.
Read More
Frequently Asked Questions
9
Bruises diminished
1 people found this helpful
Effectively! Often, bruises on the skin appeared out of nowhere. I bought this supplement to eliminate this and strengthen blood vessels. I took it with vitamin C. The changes are evident for the better. Now, I take courses twice a year. No side effects noted during use.
9
Reduces dizziness
2 people found this helpful
Upon my doctor's recommendation, I started taking Rutin alongside Vitamin C, resulting in improved health. My morning dizziness has ceased, and the recurrent nosebleeds I experienced for years have stopped. The quality and packaging of the product meet my needs splendidly.
7.5
Supports veins and gums
2 people found this helpful
I've been taking it with vitamin C to strengthen blood vessels, veins, and address bleeding gums for nearly half a year now, and everything is fine. I believe this Rutin is beneficial, especially since it carries a GMP quality mark.
9
Complications help
9 people found this helpful
Excellent! Did you know that COVID-19 (or rather, its toxin) affects the inner wall of blood vessels, making them thinner and rougher? This can lead to complications, such as blood clot formation. Rutin is an amino acid that helps address these issues. Be sure to follow the dosage instructions for at least two months during viral illnesses. Additionally, enjoy blackcurrants in summer for their high rutin content and stay healthy!
9
Reduces bruises
6 people found this helpful
I started taking this as my hands were covered in ugly bruises from even the slightest contact. Occasionally, when I scratched, blood vessels would burst too. After two weeks of use, the bruises have stopped appearing. I take it once a day after meals.
9
Improves warmth
6 people found this helpful
After years of suffering from cold hands and feet, I began taking rutin. Eventually, my extremities became too warm, prompting me to reduce my intake to a capsule once a month for maintenance. My hands and feet now feel comfortably warm. However, I would avoid this product if using blood thinners.
9
Improves overall health
2 people found this helpful
Highly recommended! The combination of rutin and vitamin C strengthens the entire vascular network, from major arteries to the tiniest capillaries. I've seen great improvements in my elderly mother's overall health from this combination.
9
Strengthens blood vessels
4 people found this helpful
Rutin greatly enhances vascular tone. Fragile capillaries often result in bruising, leading to concerns like varicose veins and inadequate blood supply. Rutin's main advantage is reinforcing blood vessel walls, not just capillaries, especially when combined with vitamin C, which it helps absorb. Moreover, while the body converts rutin into quercetin, it serves similar functions but is used in its intended application afterwards. Rutin helps dissolve blood clots and boosts immunity while providing antioxidant protection.
9
Supports vascular health
7 people found this helpful
Rutin is excellent for those with blood vessel issues from fragility to migraines. I recommend combining it with vitamin C and an anti-varicose complex. It’s irreplaceable for people facing similar problems; compared to other products, it’s far more effective!
9
Bruises ceased
1 people found this helpful
The doctor prescribed this medication alongside vitamin C 500, as I have very fragile blood vessels prone to bruises. After two weeks of taking it, I can confidently say it's beneficial! Bruises no longer appear, and the vessels are less sensitive.
9
Improves vascular health
5 people found this helpful
Rutin (vitamin P) is vital for anyone experiencing issues with veins or other vessels. Preparations containing rutin are prescribed for various conditions affecting vascular permeability: retinal haemorrhages, rheumatism, and more. I take it to improve my condition with rosacea. Rutin offers significant benefits such as an antithrombotic effect, strengthening the vascular wall, and improving blood microcirculation. For therapeutic purposes, dosages of 100-1000 mg of rutin per day are recommended, but always consult your doctor for the right amount.
7.5
Helps with fragility
3 people found this helpful
A good remedy for fortifying blood vessels. I have a diagnosis of "haemorrhoidal vasculitis", indicating fragility of blood vessels and capillaries with a tendency to bleed. Routin (rutin + ascorbic acid) is effective, strengthening capillary walls. I take 450 mg twice daily, followed by breaks.
8
Rutin:zinc complex improves anti-thrombotic activity
We explored how rutin, a natural compound found in many plants and foods, can work to prevent blood clots. While rutin is known for its anti-thrombotic properties, its low solubility has held back its effectiveness. Our study revealed that combining rutin with zinc significantly improves its solubility and makes it more effective at inhibiting harmful proteins related to blood clot formation.
In tests with mice, this rutin:zinc complex slowed down blood clots without increasing bleeding risks. This exciting finding suggests that using zinc can enhance the benefits of rutin and other flavonoids as potential treatments for blood clot issues.
In tests with mice, this rutin:zinc complex slowed down blood clots without increasing bleeding risks. This exciting finding suggests that using zinc can enhance the benefits of rutin and other flavonoids as potential treatments for blood clot issues.
9
We investigated how rutin can be effectively delivered to combat blood clots. Our study focused on creating special liposomes that can specifically target blood platelets. Through various blood tests, we found that the targeted liposomes—combined with abciximab or RGD peptide—showed significantly better antithrombotic effects than rutin alone.
Importantly, these formulations also increased the drug's bioavailability and demonstrated safety in tests with animals. Overall, targeted rutin-loaded liposomes could offer a promising approach for improving treatment against blood clots.
Importantly, these formulations also increased the drug's bioavailability and demonstrated safety in tests with animals. Overall, targeted rutin-loaded liposomes could offer a promising approach for improving treatment against blood clots.
7
We examined how rutin, a common bioflavonoid found in various foods, influences blood clotting by inhibiting protein disulfide isomerase (PDI). Previous studies indicated that rutin effectively blocks thrombosis in animal models, leading to further exploration in clinical settings. Our research highlighted a specific residue in PDI that's crucial for this interaction.
Although rutin shows promise, our findings suggest that its effectiveness is linked to certain molecular characteristics, specifically a phenoxyl group at the right position, essential for PDI inhibition. Overall, while rutin has intriguing properties, more research is needed to fully understand its role in clot regulation.
Although rutin shows promise, our findings suggest that its effectiveness is linked to certain molecular characteristics, specifically a phenoxyl group at the right position, essential for PDI inhibition. Overall, while rutin has intriguing properties, more research is needed to fully understand its role in clot regulation.
9
We explored the potential of quercetin-3-rutinoside, a compound that inhibits protein disulfide isomerase (PDI), in preventing blood clots. Through a series of tests, we found that this compound effectively stopped platelet aggregation and fibrin formation, which are crucial steps in clot development.
Using advanced imaging techniques in mice, we confirmed that quercetin-3-rutinoside successfully blocked thrombus formation. Interestingly, introducing PDI back into the system reversed its antithrombotic effects, pointing to PDI's role as a promising target for new clot-preventing treatments.
Using advanced imaging techniques in mice, we confirmed that quercetin-3-rutinoside successfully blocked thrombus formation. Interestingly, introducing PDI back into the system reversed its antithrombotic effects, pointing to PDI's role as a promising target for new clot-preventing treatments.
References
- Liao X, Ji P, Chi K, Chen X, Zhou Y, et al. Enhanced inhibition of protein disulfide isomerase and anti-thrombotic activity of a rutin derivative: rutin:Zn complex. RSC Adv. 2023;13:11464. doi:10.1039/d3ra01135f
- Priya V, Singh SK, Revand R, Kumar S, Mehata AK, et al. GPIIb/IIIa Receptor Targeted Rutin Loaded Liposomes for Site-Specific Antithrombotic Effect. Mol Pharm. 2023;20:663. doi:10.1021/acs.molpharmaceut.2c00848
- Wang Y, Wu H, Sheng H, Wang Y, Li X, et al. Discovery of anti-stroke active substances in Guhong injection based on multi-phenotypic screening of zebrafish. Biomed Pharmacother. 2022;155:113744. doi:10.1016/j.biopha.2022.113744
- Chen D, Liu Y, Liu P, Zhou Y, Jiang L, et al. Orally delivered rutin in lipid-based nano-formulation exerts strong antithrombotic effects by protein disulfide isomerase inhibition. Drug Deliv. 2022;29:1824. doi:10.1080/10717544.2022.2083726
- Liao X, Zhuang X, Liang C, Li J, Flaumenhaft R, et al. Flavonoids as Protein Disulfide Isomerase Inhibitors: Key Molecular and Structural Features for the Interaction. J Agric Food Chem. 2022;70:4475. doi:10.1021/acs.jafc.1c07994
- Zaragozá C, Monserrat J, Mantecón C, Villaescusa L, Álvarez-Mon MÁ, et al. Binding and antiplatelet activity of quercetin, rutin, diosmetin, and diosmin flavonoids. Biomed Pharmacother. 2021;141:111867. doi:10.1016/j.biopha.2021.111867
- Wu H, Su M, Jin H, Li X, Wang P, et al. Rutin-Loaded Silver Nanoparticles With Antithrombotic Function. Front Bioeng Biotechnol. 2020;8:598977. doi:10.3389/fbioe.2020.598977
- Qin RR, Zhu H, Wang F, Song M, Lin PL, et al. Platelet activation in diabetic mice models: the role of vascular endothelial cell-derived protein disulfide isomerase-mediated GP IIb/IIIa receptor activation. Aging (Albany NY). 2019;11:6358. doi:10.18632/aging.102192
- Yildiz CE, Conkbayir C, Huseynov E, Sayin OA, Tok O, et al. The efficiency of O-(beta-hydroxyethyl)-rutosides in reducing the incidence of superficial venous insufficiency in patients with calf muscle pump dysfunction. Phlebology. 2017;32:179. doi:10.1177/0268355516635466
- Smyth RM, Aflaifel N, Bamigboye AA. Interventions for varicose veins and leg oedema in pregnancy. Cochrane Database Syst Rev. 2015;2015:CD001066. doi:10.1002/14651858.CD001066.pub3
- Lin L, Gopal S, Sharda A, Passam F, Bowley SR, et al. Quercetin-3-rutinoside Inhibits Protein Disulfide Isomerase by Binding to Its b'x Domain. J Biol Chem. 2015;290:23543. doi:10.1074/jbc.M115.666180
- Giannini I, Amato A, Basso L, Tricomi N, Marranci M, et al. Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial. Tech Coloproctol. 2015;19:339. doi:10.1007/s10151-015-1302-9
- Choi JH, Kim DW, Park SE, Lee HJ, Kim KM, et al. Anti-thrombotic effect of rutin isolated from Dendropanax morbifera Leveille. J Biosci Bioeng. 2015;120:181. doi:10.1016/j.jbiosc.2014.12.012
- Kim DS, Ji HD, Rhee MH, Sung YY, Yang WK, et al. Antiplatelet Activity of Morus alba Leaves Extract, Mediated via Inhibiting Granule Secretion and Blocking the Phosphorylation of Extracellular-Signal-Regulated Kinase and Akt. Evid Based Complement Alternat Med. 2014;2014:639548. doi:10.1155/2014/639548
- Jang JW, Lee JK, Hur H, Kim TW, Joo SP, et al. Rutin improves functional outcome via reducing the elevated matrix metalloproteinase-9 level in a photothrombotic focal ischemic model of rats. J Neurol Sci. 2014;339:75. doi:10.1016/j.jns.2014.01.024
- Jasuja R, Passam FH, Kennedy DR, Kim SH, van Hessem L, et al. Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents. J Clin Invest. 2012;122:2104. doi:10.1172/JCI61228
